The Chairboys totally dominated the game but could not find the net with prolific scorers Jermaine Easter and Tommy Mooney shut out by the Lincoln defence.
The Imps took advantage to snatch a late winner from one of their few attacking moves of the game.
Wycombe controlled things from the start with midfielder Stefan Oakes firing inches over in the first minute.
Wanderers had a great chance in the 17th minute when Kevin Betsy forced his way down the right flank and sent over a perfect cross which found the head of Mooney. The striker's looping header looked destined for the top corner but Lincoln keeper Alan Marriott brought off a superb one-handed save.
That was the start of a man-of-the-match performance from the former Tottenham stopper who at times defied the Wycombe attack single-handedly.
Marriott threw himself to his left to keep out a 22nd minute shot from Anthony Grant and then did well when Michael Williamson powered in a header.
Marriott saved well again from Mooney and Betsy as Lincoln were cut apart time and time again.
Lincoln failed to manage a single shot in the first 72 minutes but suddenly left Wycombe stunned.
Scott Kerr put in Mark Stallard who was allowed to continue despite looking well off-side but sent a weak shot straight at keeper Jamie Young.
Lincoln snatched the winner 60 seconds later with a breakaway goal. Highly rated midfield man Lee Frecklington opened up the Wycombe defence and winger Jeff Hughes timed his run perfectly, drawing the keeper before calmly firing a left-foot shot into the net for his fifth goal of the season.
Hughes almost got another goal five minutes later with a solo effort. He tricked his way past two defenders on the left and blasted in a low shot which brought an excellent save from Young.
But Wycombe kept pushing forward and Oakes was unlucky ten minutes from time when his 30-yard shot beat Marriott but crashed against the bar.
Then a great cross from Betsy picked out Ikechi Anya at the far post but the substitute headed wide when it looked easier to score.