The away side dominated the first 20 minutes and nearly took the lead when Lee Frecklington's speculative 25-yard effort caught Frank Fielding off his line.
But Wycombe, who had offered nothing going forward, were given a lifeline on the half hour when referee Salisbury sent off Oliver Ryan for his dangerous lunge on Will Antwi.
The home side nearly made their numerical advantage count a minute later, but Martin Bullock's superb volley crashed back off the bar.
The eleven men continued to press and were rewarded five minutes before the break when top scorer Scott McGleish finished off a great move to give the home side the lead.
The game could have been out of the Imps' reach on the hour but Sergio Torres couldn't direct his shot after breezing past two Lincoln defenders.
In search of that elusive second, left-back Sam Stockley took matters into his own hands and was only a yard away from doubling the home side's lead.
Despite having ten men Lincoln continued to go in search of that deserved equaliser, but at times leaving themselves open in defence.
Then a moment of brilliance from Torres nearly secured the points for the home side, but his thunderous 25-yard shot came back off the post.
Lincoln threw on all three substitutions to try and get a result and Peter Jackson's decision nearly paid off. Hamza Bencherif was set away down the left and after shaking off his marker put a great cross in.
Lenell John-Lewis came powering in but couldn't quite direct his shot on goal which would have seen a dramatic end to what was a dull game.